Associate Scientist /Sr. Associate Scientist Upstream Process D
Zoetis is a global animal health company dedicated to supporting customers and their businesses in ever better ways. Building on 60 years of experience, we deliver quality medicines and vaccines, complemented by diagnostic products and genetic tests and supported by a range of services. We are working every day to better understand and address the real-world challenges faced by those who raise and care for animals in ways they find truly relevant.Our name, Zoetis (z-EH-tis), has its root in zo, familiar in words such as zoo and zoology and derived from zoetic, meaning “pertaining to life.” It signals our company”s dedication to supporting the veterinarians and livestock producers everywhere who raise and care for the farm and companion animals on which we all depend.Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.JOB DESCRIPTION The Associate / Senior Associate Scientist in upstream bioprocess development plays an essential role in the Zoetis vaccine and biopharmaceutical strategies for veterinary medicine. The successful applicant will work as a team member in the development of fermentation and bioreactor protocols in support of global product development and GMP (Good Manufacturing Practice) manufacture of biological veterinary products. The incumbent is expected to work hands-on at the bench while providing technical support to project teams within the discipline of biological manufacturing science. The Associate / Senior Associate Scientist is expected to work with a minimal degree of autonomy in the discipline and work on project teams in partnership with colleagues in downstream process development, formulation development, and bioanalytical science. To be successful, they will have basic knowledge of platforms for cultivation of wild type micro-organisms and host prokaryotic systems for expression of recombinant proteins such as protein expression in prokaryotic or yeast hosts. They will have a working knowledge of related bioprocessing unit operations such as cell line development and/or seed banking. The position is based in Lincoln (Nebraska, USA) with frequent interactions with colleagues and external partners located around the globe.POSITION RESPONSIBILITIES * Apply a basic knowledge of biological manufacturing science in the design and execution of bioreactor experiments to identify and validate critical parameters that affect upstream bioprocess performance across multiple scales. The parameters to be investigated may include reactor configuration, medium formulation, and fed-batch strategies. * Working with senior level Scientists to systematically optimize the parameters that affect bioreactor performance through the application of statistical models for experimental design and analysis. * Work in collaboration with colleagues in pilot and manufacturing scale operations to devise scale-up strategies for fermentation processes. Provide technical guidance in scale up programs based on risk assessment of critical parameters and their impact on product quality attributes. * Serve as a technical resource to project teams by providing the essential expertise in biological manufacturing science required for successful project delivery. This includes a willingness to share experimental findings with team members, peers, and management. * Drive innovation and continuous improvement by conducting laboratory experiments to evaluate new bioprocess technologies. * Partner with scientists working in molecular biology and cell line development to conduct screening experiments with purpose to identify high-performing microbial strains. * Document experimental findings through periodic authorship of progress reports that will be included in dossiers for product registration and technology transfer. Serve as a technical expert to project teams * Maintain electronic laboratory notebooks and records in accord with scientific protocol and applicable Standard Operating Procedures. ORGANIZATIONAL RELATIONSHIPS * The position is located in the Biological Development line within Laboratory Sciences. The Associate / Senior Associate Scientist will interact with peers and colleagues working in disciplines that include bioanalytical science, vaccine research, downstream processing, and formulation development. * This position involves end-to-end contribution across the life cycle of new product development from the research phase through to process design, scale-up, and transfer into manufacturing operations. The position works in partnership with colleagues in Global Biologicals Research to generate materials required for research studies. The position also involves working in partnership with colleagues in seed banking, pilot operations, and manufacturing in order to ensure efficient technical transfer of new candidates into GMP manufacturing operations. * The Associate / Senior Associate Scientist is expected to form collaborative working relationships with project team leaders and line representatives within team settings. * Interaction with colleagues working in regulatory affairs for dossier preparation. EDUCATION AND EXPERIENCE * BSc, MSc in microbiology, cell biology and physiology, chemical or biochemical engineering with 2-5 years” experience in the industry for bioprocess development for manufacturing of high-value biological products. * Demonstrated track record as a researcher working in the field of bioprocess development. TECHNICAL SKILLS REQUIREMENTS * Basic theoretical knowledge of the scientific disciplines that support bioprocess development and scale-up such as cell biology, industrial microbiology, or biochemical engineering
* Basic hands-on practical experience with one or more systems involving cultivation of wild type micro-organisms, yeasts, or prokaryotes for recombinant protein expression. Basic knowledge in the design and optimization of these systems to deliver cost-effective and robust manufacture of antigens or recombinant proteins in accord with the requirements of GMP. * Experience with in-process analytical systems to monitor and control bioreactor experiments such as cell counting, metabolite profiling, and protein quantification. * Excellent aseptic technique. * Working knowledge of the principles for experimental execution using the methodologies of statistical Design of Experiments (DOE). * Experience in scaling up bioreactor systems and technical transfer into manufacturing operations. Design and qualification of scale down models of bioreactor unit operations for the conduct of studies for bioprocess characterization. * Demonstrated track record working as a scientific collaborator on multiple concurrent programs. * A willingness to embrace and evaluate new technologies for the purpose to improve existing capabilities and workflows within the line. * Knowledge of the regulatory (USDA, FDA, EMA) expectations for bioprocess design and technical transfer in alignment with principles of GMP. * Excellent written and verbal communication skills.