Post-Doctoral Research: Protein Therapeutics and Protein Design
Zoetis is a global animal health company dedicated to supporting customers and their businesses in ever better ways. Building on 60 years of experience, we deliver quality medicines and vaccines, complemented by diagnostic products and genetic tests and supported by a range of services. We are working every day to better understand and address the real-world challenges faced by those who raise and care for animals in ways they find truly relevant.Our name, Zoetis (z-EH-tis), has its root in zo, familiar in words such as zoo and zoology and derived from zoetic, meaning “pertaining to life.” It signals our company”s dedication to supporting the veterinarians and livestock producers everywhere who raise and care for the farm and companion animals on which we all depend on.Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact.Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of “@zoetis.com”. In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.Post-Doctoral Researcher: Protein Therapeutics and Protein DesignThe Protein Therapeutics group is seeking a talented and experienced protein engineer to contribute to our efforts in Global Therapeutics Research at Zoetis. The Protein Therapeutics group partners with therapeutic areas and project teams to design and engineer novel biotherapeutics and build robust testing funnels for a variety of therapeutic approaches to improve diseases in companion animals as well as livestock species. The successful candidate should have knowledge of antibodies and/or protein interactions and relevant experience with in silico protein homology models, protein docking, and epitope mapping. Experience with and understanding of peptide design, protein design and engineering, molecular biology, and protein characterization is preferred. Excellent communication, organizational and interpersonal skills are essential. Some travel required depending on location of candidate. POSITION RESPONSIBILITIES: * Protein and antibody in silico design and structural mapping * Epitope mapping and immunogen design * Antibody optimization and affinity maturation using rational design techniques * Collaborate across multiple scientific disciplines to understand mechanistic biology * Directly communicate with external partners for collaborations and outsourcing.
EDUCATION AND EXPERIENCE: * Educational background: Ph.D. in engineering, molecular or cellular biology, immunology, biochemistry, or related field. * Training or experience in biological sciences focusing on protein engineering and protein modeling with an emphasis on understanding epitopes and protein-protein interactions. * Expertise in protein modeling techniques including homology modeling, epitope/paratope mapping, in silico protein optimization, and immunogen design. * Exposure to affinity maturation & antibody optimization approaches (phage, yeast, mammalian, or mRNA display; rational design techniques) preferred. * Some experience with molecular biology and molecular cloning techniques including subcloning, site-directed mutagenesis, PCR and DNA manipulation is desired. * Exposure to protein expression & isolation (mammalian & bacterial systems), affinity chromatography, protein biochemistry and protein quantification (SDS-PAGE protein gels, Westerns, analytical SEC, ELISAs, SPR) is a plus. * Self-starter, able to prioritize work and work efficiently, design experiments with minimal supervision, and able work across teams remotely and face-to-face. * Experience interacting with CROs or external partnerships * Excellent verbal/written communication, organizational and interpersonal skills * Computer skills required: Microsoft Word, Excel, Outlook, BLAST, Vector NTI or equivalent, protein modeling software (MOE, Rosetta, etc.)
ADDITIONAL INFORMATION:* Work environment: The placement of this position will be in Boulder, CO. This person will be expected to travel occasionally to R&D Headquarters (Kalamazoo, MI).