Post-doctoral scientist-Epigenetics

Job Listing No: 9740000

Post-doctoral scientist-Epigenetics

Zoetis is a global animal health company dedicated to supporting customers and their businesses in ever better ways. Building on 60 years of experience, we deliver quality medicines and vaccines, complemented by diagnostic products and genetic tests and supported by a range of services. We are working every day to better understand and address the real-world challenges faced by those who raise and care for animals in ways they find truly relevant.Our name, Zoetis (z-EH-tis), has its root in zo, familiar in words such as zoo and zoology and derived from zoetic, meaning “pertaining to life.” It signals our company”s dedication to supporting the veterinarians and livestock producers everywhere who raise and care for the farm and companion animals on which we all depend on.Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact.Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of “@zoetis.com”. In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.The Global Therapeutics Research group seeks a post-doctoral scientist to develop in vitro assays that can support mechanistic understanding of the epigenetic regulation. The main area of emphasis will be immune related phenomena such as innate immune training, tolerance induction, and the role of epigenetics in inflammatory diseases.The postdoc will develop methods for chromatin isolation and targeted mass spectrometry using e.g. locus, genomic DNA pulldown approaches.The candidate should have experience in immune cell isolation, monocyte differentiation, functional assays, and immuno-phenotyping. The candidate should also have a strong desire to collaborate with multiple functions including the mass spectrometry and biology teams to develop the ChIP-MS methodsThe successful candidate should have completed a PhD in immunology or cell biology with an emphasis on epigenetics. In addition, the candidate should have been exposed to mass spectrometry based proteomics. The candidate should have excellent communication, organizational and interpersonal skills. POSITION RESPONSIBILITIES: * Define, build, and execute appropriate proteomic study designs to identify putative epigenetic regulation sites. * Work closely with biology team to design proper plans to avoid pre-analytical artifacts during sample collection and processing. * Work closely with bioinformatics to identify key loci to examine epigenetic regulation. * Present results to scientific teams and management. EDUCATION AND EXPERIENCE:* Educational background: PhD (Biochemistry, cell and molecular biology, immunology, or related field)* Strong analytical experience in top down and bottom up proteomics.* Familiar with the operation of Sciex triple quadrupole, Thermo Q-Exactive series, Waters triple quadrupole and QTOF mass spectrometers* Experienced with relative and absolute quantification proteomic workflows (TMT, SILAC, SRM, PRM, label-free, etc)* Familiarity with proteomic and LC-MS software (Skyline, MaxQuant, BioPharma Finder, Analyst, MassLynx, Xcalibur, TraceFinder, BLAST, alignment tools, etc)* Self-starter, able to prioritize work and work efficiently with minimal supervision* Excellent verbal/written communication, organizational and interpersonal skills* Computer skills required: Microsoft Word, Excel, OutlookADDITIONAL INFORMATION:* Work environment: The person filling this position will work predominantly in a laboratory setting. There may be exposure to animal pathogens and chemicals. There may be handling of, and/or exposure to animal tissue and zoonotic organisms

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