Scientist/Sr Scientist – Ligand Binding Assays

Job Listing No: 9740000

Scientist/Sr Scientist – Ligand Binding Assays

Zoetis is a global animal health company dedicated to supporting customers and their businesses in ever better ways. Building on 60 years of experience, we deliver quality medicines and vaccines, complemented by diagnostic products and genetic tests and supported by a range of services. We are working every day to better understand and address the real-world challenges faced by those who raise and care for animals in ways they find truly relevant.Our name, Zoetis (z-EH-tis), has its root in zo, familiar in words such as zoo and zoology and derived from zoetic, meaning “pertaining to life.” It signals our company”s dedication to supporting the veterinarians and livestock producers everywhere who raise and care for the farm and companion animals on which we all depend on.Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact.Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of “@zoetis.com”. In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.In the Pharmacokinetic Pharmacodynamic and Metabolism (PDM) department at Zoetis, we are a leading bioanalytical group for PK/PD sciences, novel technologies, and immunoassay development that support the development of important medicines for patients. We do this by fostering an innovative and collaborative environment that values and recognizes a diversity of contributions. The PDM department is seeking a highly motivated, flexible, Scientist/Sr. Scientist to develop large molecule and biomarker bioanalytical methods and strategies supporting the biopharmaceutical portfolio.Responsibilities for this position include development and implementation of immunoassay methods, managing flexible timelines and resources to meet project goals. Working with scientific staff, this individual develops, characterizes, and qualifies in vitro immunoassay methods to quantify biotherapeutic levels in various species and biological matrices, to detect and characterize immune responses evoked by the biotherapeutic, to measure biomarkers, and to conduct biological characterization in support of regulatory filings, and to work with contract research organizations to transfer and validate assays. This will involve laboratory work, the use of automation systems and use of various assay platforms, including ELISA, Quanterix, Mesoscale Discovery, Gyros and Luminex. The individual will work independently and in collaboration with colleagues within PDM and across various functional areas in research, to develop, optimize and qualify analytical methods in support of both in vitro and in vivo nonclinical and clinical studies. This person will provide analytical support to programs from early development through clinical studies and regulatory filings.Experience: * Strong background in all aspects of immunoassay development including antigen and antibody selection, antibody matched pair screening and optimization, binding kinetics, and multiplexing * Develop, qualify and validate immunoassays on various platforms including but not limited to; ELISA, Quanterix, Mesoscale Discovery, Gyros and Luminex. * Reagent characterization using the Octet or Biacore * Protein labeling * Reviews, interprets and analyzes data for technical, quality and compliance to protocols, methods and SOPs. * Ability to utilize Microsoft Excel and Word to perform task * Proven problem solving and troubleshooting abilities * Effective oral and written communication skills * Proven ability in technical writing skills * Time management and project management skills * Ability to work in a collaborative work environment with a team * Proven problem solving and troubleshooting abilities * Design of complex laboratory experiments * Modeling and data analysis of multiplexed assay results * Contribute to the creation of innovative solutions * Demonstrated ability to contribute effectively to cross-functional process development, improvement, and troubleshooting teams * Provide subject matter expertise as needed * Maintain appropriate documentation and lab notebook * Independently research and locate sources for reagents and other biological sources * Troubleshoot equipment and resolve issues with minimal assistance * Train staff biologists and lab technicians in different experimental techniques as needed * Publish original research and present at technical meetings as neededSkills and Experience Required:
* Strong background in all aspects of immunoassay development including antigen and antibody selection, antibody matched pair screening and optimization, binding kinetics, and multiplexing * Knowledge of antibody production, purification, and conjugation methods * Knowledge of cell and/or tissue culture * Experience with developing assays to test complex biological samples * Experience with multiple detection systems * Experience with troubleshooting complex projects * Strong understanding of experimental design * Strong analytical and communication skills * Excellent interpersonal skillsExperience in an industrial setting is preferred, and knowledge of immunoassay development is required. The individual should have an in-depth understanding and hands-on experience in developing quantitative analyte assays for protein therapeutics or biomarkers in particular utilizing various immunoassay platforms. The work will require the application of immunoassays as well as state-of-the-art assay technologies such as Quanterix, Ella, Singulex, Gyros and Luminex and other biochemical approaches. Expertise with standard text, graphic, and presentation software is required, and familiarity with database/data archival software systems is helpful. Excellent communication, interpersonal and organizational skills are essentialEducation:
* BS in Biochemistry or related field with at least 5 to 10 years of relevant experience * MS in Biochemistry or related field with at least 3 to 5 years of relevant experience

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