Senior/Principal Scientist: Targeted Protein Quantification

Job Listing No: 9740000

Senior/Principal Scientist: Targeted Protein Quantification

Zoetis is a global animal health company dedicated to supporting customers and their businesses in ever better ways. Building on 60 years of experience, we deliver quality medicines and vaccines, complemented by diagnostic products and genetic tests and supported by a range of services. We are working every day to better understand and address the real-world challenges faced by those who raise and care for animals in ways they find truly relevant.Our name, Zoetis (z-EH-tis), has its root in zo, familiar in words such as zoo and zoology and derived from zoetic, meaning “pertaining to life.” It signals our company”s dedication to supporting the veterinarians and livestock producers everywhere who raise and care for the farm and companion animals on which we all depend on.Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact.Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of “@zoetis.com”. In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.Position SummaryWe are seeking a talented scientist to join our team to discover novel therapeutics for veterinary medicine. This position will require a highly motivated and independent scientist who can effectively collaborate with other team members to advance projects. Specifically, we are looking for a scientist to join our PDM team focusing on the quantification of protein therapeutics and identification/quantification of protein biomarkers in biological matrices using LC-MS approaches. Responsibilities * Independent hands-on development of new LC-MS methods to quantify protein therapeutics and protein biomarkers in biological matrices such as serum, tissue, and cell culture * Implement proteomic/chemoproteomic strategies to support drug discovery * Work with study directors to provide assay support to studies within agreed upon timelines * Prepare reports and present results to scientific teams and management * Consult with project teams and independently design experiments to fit the strategic direction of the teams * Train and mentor other scientists Minimum Qualifications * PhD in Biochemistry, Chemistry, or related discipline with a minimum of 5 years experience in protein mass spectrometry. BS/MS with a minimum of 10 years of experience may also be considered. * Demonstrated ability to develop, optimize, and perform LC-MS methods for protein and peptide quantitative analysis in biological matrices (serum, tissue, cell culture). Proven track record of success including peer reviewed publications. * Experienced with protein digestion using selective proteases and selection of surrogate peptides for proteins by LC/MS and in silico prediction software tools * Expert with standard HPLC/UPLC-, micro- and nano-LC/MS method development. Experience with 2D- or 3D-LC is highly desirable * Experienced with immunoaffinity purification of proteins * Experienced with the proper handling and storage of proteins * Experienced with relative and absolute quantification proteomic workflows (TMT, SILAC, SRM, PRM, label-free) * Familiarity with proteomic and LC-MS software (Skyline, MaxQuant, BioPharma Finder, Analyst, MassLynx, Xcalibur, TraceFinder, BLAST, alignment tools) * Highly independent with the ability to innovate within the discipline and effectively collaborate with other small molecule and protein scientists to share best practices and troubleshoot assays * Excellent written and oral communication skills
Desirable skills * Familiar with the operation of Sciex triple quadrupole, Thermo Q-Exactive series, Waters triple quadrupole and QTOF mass spectrometers * Familiarity with chemoproteomic approaches * Familiarity with ligand binding assays (e.g. ELISAs) on various platforms such as MSD or Gyrolab. * Experienced with characterization of proteins (e.g. gel electrophoresis, HPLC-size exclusion chromatography, etc.) * Experienced with LIMS and PK software, such as WinNonlin, Watson, and others. * Experienced with monitoring work at CROs

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