Sr Associate Scientist – Assay Design and Protein Therapeutics
Zoetis is a global animal health company dedicated to supporting customers and their businesses in ever better ways. Building on 60 years of experience, we deliver quality medicines and vaccines, complemented by diagnostic products and genetic tests and supported by a range of services. We are working every day to better understand and address the real-world challenges faced by those who raise and care for animals in ways they find truly relevant.Our name, Zoetis (z-EH-tis), has its root in zo, familiar in words such as zoo and zoology and derived from zoetic, meaning “pertaining to life.” It signals our company”s dedication to supporting the veterinarians and livestock producers everywhere who raise and care for the farm and companion animals on which we all depend.Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.Senior Associate Scientist – Assay Design and Protein Therapeutics Group – Antibody EngineerThe Assay Design and Protein Therapeutics group is seeking a talented and experienced molecular biologist / protein engineer to contribute to our efforts in Global Therapeutics Research at Zoetis. The ADaPT group partners with therapeutic areas and project teams to design and engineer novel substrate and build robust testing funnels for a variety of therapeutic approaches that improve diseases or conditions in companion animals as well as livestock species.
The successful candidate should have at least 1 year of relevant experience in molecular biology, protein design and engineering, and protein characterization. Experience with and understanding of display technologies, library design, and next-generation sequencing is preferred but not required. Knowledge of antibodies and/or protein interactions is a plus. Excellent communication, organizational and interpersonal skills are essential. POSITION RESPONSIBILITIES: * Molecular biology and mutagenesis including subcloning, site-directed mutagenesis, PCR and DNA manipulation. * Protein and antibody in silico design * Protein expression & isolation * Protein characterization including SDS-PAGE protein gels, Westerns, analytical SEC, ELISAs, SPR * Affinity maturation & antibody optimization (phage, yeast, mammalian, or mRNA display; rational design techniques) * Collaborate across multiple scientific disciplines EDUCATION AND EXPERIENCE: * Educational background: BS or MS (molecular or cellular biology, immunology, biochemistry, engineering, or related field). * Training or experience in biological sciences focusing on protein engineering, molecular biology, protein expression, purification, and characterization. * Experience with molecular biology and molecular cloning techniques including DNA and RNA isolation, PCR, and mutagenesis. * Experience with bacterial and mammalian expression systems, affinity chromatography, and protein quantification. * Experience in protein biochemistry, including SDS PAGE protein gels, Western gels, ELISA, and analytical SEC. * Some experience generating or working with DNA libraries for display or next-generation sequencing is desired. * Self-starter, able to prioritize work and work efficiently with minimal supervision and work across teams * Excellent verbal/written communication, organizational and interpersonal skills * Computer skills required: Microsoft Word, Excel, Outlook, BLAST, Vector NTI or equivalent ADDITIONAL INFORMATION:Work environment: The person filling this position will work predominantly in a laboratory setting. There may be exposure to animal pathogens and chemicals. There may be handling of, and/or exposure to animal tissue and zoonotic organisms